The Sanzo Ikkou continues its westward journey, on a mission to prevent a demonic resurrection. As Genjo Sanzo, Cho Hakkai, Sha Gojyo, and Son Goku fight their way to their goal, their path is fraught with internal strife. When they encounter a formidable pair of adversaries from the west, the cohesion of the group -- and the fate of the mission -- may be at stake.

Saiyuuki Reload Gunlock adapts parts of Saiyuuki Reload manga's Vol. 2, also Saiyuuki Reload manga's Even a Worm arc with changes to the source material including an anime original ending.