In the events to follow the Third Great Shinobi War, Hinoe accompanied Danzou Shimura to a meeting with Orochimaru after the latter had been passed over for the position as Hokage. With nine other Root members, Hinoe received a mission to assassinate Hiruzen Sarutobi before he could be reinstated as Hokage. Disguised as a foreign shinobi, he fought the Anbu accompanying his target, who turned out to be a disguised Kakashi.